The aim of the present study was designed to develop model controlled release matrix tablet formulations for propranolol hydrochloride. Propranolol hydrochloride tablets were prepared by using different drug: gum ratios of guar gum, gum karaya alone and a mixture of guar gum and karaya gum (in 1: 1 ratios) by wet granulation method. The influence of the proportion of the gum on the release rate of the drug from the tablets was studied. The tablets were analyzed to determine their hardness, friability, dug content and in vitro release profile. The release of the drug is by diffusion and swelling controlled mechanisms exhibiting non-Fickian transport. The matrices containing blend of gums exhibited precise controlled release than the guar gum and karaya gum matrices because of burst effect and fast release in case of guar gum and much slow release in case of karaya gum. The first-pass effect of propranolol can be avoided by using this formulation.
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